9/19/2023 0 Comments Estrogen and caffeine half life![]() otherwise it will be difficult for me to fall asleep at night,” she said. “For someone like me who does have that genetic variant, I do not have caffeine after 8 a.m. That said, knowing that she has this genetic variant has helped her consume caffeine more strategically. Lester is a slow caffeine metabolizer herself and still enjoys her daily dose of caffeine. So if you’re a slow caffeine metabolizer, should you be cutting out caffeine from your routine entirely? “No way!” said Dr. The CYP1A2 gene made headlines a few years ago when a study, published in the Journal of the American Medical Association, showed that slow metabolizers who drink more than four cups of coffee per day have an increased risk for heart disease. If you’re a slow metabolizer, should you avoid caffeine? “It usually comes up if a patient has done a 23andMe or other direct-to-consumer genetic test,” she continued. In other words, it doesn’t influence health in a significant enough way that she would go out of her way to order the test for every single one of her patients. “I don’t typically test for CYP1A2 in isolation,” explained Dr. But how do you test it to know for sure? You can test for the caffeine gene through a simple saliva or blood test that analyzes your DNA. How to test for the CYP1A2 geneīased on your reaction to caffeinated beverages, you probably already have a hunch as to whether you’re a fast or slow caffeine metabolizer. ![]() In contrast, if you have one or two versions of the “slow” version of CYP1A2, you’re labeled a “slow” caffeine metabolizer, meaning you clear caffeine from your system about four times slower than your quick metabolizing counterparts, says Dr. , physician and medical director at Parsley Health San Francisco, “These are the people that can have an espresso and go right to sleep!” If you have two “fast” versions, you’re considered a fast caffeine metabolizer. You have two copies of the CYP1A2 gene-one inherited from each of your parents-and each can be either a “fast” or “slow” version of the gene. The speed of this decline depends on your CYP1A2 gene, which controls an enzyme (also called CYP1A2) that is in charge of breaking down any caffeine that enters the body. Your caffeine levels peak about 1-hour after consumption and then start to decrease gradually. The caffeine you ingest passes through the stomach and small intestine, entering the bloodstream in a little as 15 minutes. Recently, researchers discovered these variations in caffeine tolerance can be traced back to genetic differences, which brings us to the CYP1A2 gene. It’s often described as a cognitive and physical performance enhancer. Everyone seems to react to caffeine differently some get jittery and anxious from a few sips of coffee while others can drink cup after cup without blinking an eye. To get specific, caffeine targets the central nervous system and makes you feel more awake, energized, and alert. Caffeine acts as a natural stimulant and for this reason, the FDA has it listed as both a food and a drug. What is caffeine-and how does it affect the body?Ĭaffeine is a bitter, white substance that’s found naturally in more than 60 different plants, including coffee beans, tea leaves, and kola nuts, which are used to make soda. More specifically, it may depend on one gene-called CYP1A2-that determines how your body metabolizes the caffeine found in fan favorite beverages like tea, coffee, and soda. Is caffeine bad for you? It may depend on your genes. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: A prospective analysis of up to 347,077 individuals and 8368 cases. Committee Opinion No.462: Moderate caffeine consumption during Pregnancy. American College of Obstetricians and Gynecologists.International Agency for Research on Cancer 2018. In: IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. 116: Drinking coffee, mate, and very hot beverages. IARC Working Group on the Evaluation of Carcinogenic Risk to Humans.Coffee for cardioprotection and longevity. Coffee, caffeine, and health outcomes: An umbrella review. Benefits and risks of caffeine and caffeinated beverages. Journal of the American Academy of Nutrition and Dietetics. adults based on the NHANES 20072012 surveys. Daily patterns of caffeine intake and the association of intake with multiple sociodemographic and lifestyle factors in U.S.
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